I've created a custom InDesign-based scripting solution that allows the graphic designers at the Congressional Budget Office to design their print content in InDesign and output to PDF as they have always done. Then, they run a script that converts the document to HTML that is ready to automatically ingest into their Drupal-based CMS and post on their Web site. This system allows them to publish to PDF and mobile-friendly HTML simultaneously from the same InDesign source file.
You can view lots of examples here.
"I'm thrilled with your work. You've built...an astonishingly useful system." - J.S.